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APSA's 9th Annual Meeting

April 26-28, 2013
Fairmont Chicago Millennium Park
Chicago, IL USA

APSA’s 9th Annual Meeting will be held in Chicago on April 26-28, 2013 in conjunction with the annual meetings of the American Society for Clinical Investigation (ASCI) and the Association of American Physicians (AAP). This joint meeting will feature cutting edge research from physician-scientists across the country. The agenda includes numerous keynote addresses in addition to expert panels, student talks, a black tie dinner, and an evening at the Willis (Sears) tower. Register today!

Key Deadlines

Abstract deadline: December 19, 2012, 12 midnight EST
Early registration deadline: April 11, 2013
Hotel room discount (subject to availability): March 29, 2013
Advance registration deadline: April 24, 2013

2013 APSA Annual Meeting Committee

Vice President/Events: Taylor Heald-Sargent, Loyola University Chicago

Chair: Katherine Hartmann, The Ohio State University

Vice Chair: Steven Back, Temple University School of Medicine

Vice Chair: Daniel DelloStritto, Northeast Ohio Medical University

Vice Chair: Sherry Wen, Vanderbilt University

Adrienne Barry, University of Illinois at Urbana-Champaign

Naty Chaimowitz, Virginia Commonwealth University

Dylan Dodd, University of Illinois at Urbana-Champaign

Krishna Sarma, University of Nebraska Medical Center

Ali Sovari, University of Illinois at Chicago

Brittany Weber, University of Pennsylvania

Lyn Nguyen, University of Utah

Steven Scoville, The Ohio State University

Jonathan Scoville, University of Cincinnati

Vida Chitsazzadeh, University of Texas Medical School at Houston

 

Submit an abstract for 2013 poster presentation sessions

Almost 200 posters were presented in 2012 and we look forward to another stimulating exhibit hall full of new and ongoing research findings. Lunch will be served in the poster hall again in 2013 and we encourage all attendees to talk with poster presenters during that time. There will be a small number of top scoring abstracts submitted as posters chosen for an oral presentation on Sunday morning, April 28. Presenters selected must be available at this time to present their work.

Poster Session

 

Poster Size: 4 feet high by 4 feet wide (You will be sharing the poster board with another

Presenter, so you must keep to this size. They will be side-by-side. You will each

have the same amount of space on a board size 4 ft by 8 ft)

Presentation Time: Saturday, April 27, 2013 - 11:45 am – 1:30 pm

Mount Time: Friday, April 26, 2013 between 1:00 pm-3:00 pm

Dismount: Saturday, April 27 from 1:30 pm – 2:00 pm

Location: Imperial Ballroom

Presenters must be at their posters from 11:45 a.m. to 1:30 p.m., on Saturday, April 27. Presenters are not required to be present during all viewing hours.

The presenting author must be positioned at the poster board during the presentation time (11:45 am – 1:30 pm). One or two authors should be in attendance during the presentation time as all posters will have reviewers assigned to stop by to discuss your poster. The poster board area is approximately 4 feet high by 4 feet wide. Please bring your own push-pins. If you are unable to present your poster, please email admin@aap-online.org.

 

Content

A poster is a visual presentation of your research or clinical project. Use schematic diagrams, graphs, tables and other strategies to direct the visual attention of the viewer, rather than explaining it using text as you would in a journal article.

A poster addresses one central question. State the question or hypothesis clearly in the poster and use your presentation to provide a clear and explicit take-home message. Posters usually have a similar structure to a research paper or journal article: an abstract, introduction(i.e., brief rationale or review of relevant research), methodsection, resultssection, and a conclusionor summary. If your poster is more clinically-oriented, you may elect to use a different format, but breaking things down into clear sections with headings will help your colleagues understand your poster easily and quickly.

In the busy and crowded environment of a poster session, most people do not have the ability to read and process long sections of text. Therefore, keep text to the bare essentials and stick to the most important ideas. You can convey details via discussion when you are standing by your poster.

Format

·Use bullet points to simplify sections like the introduction and conclusions.

·Use large type, such as 36-point type for section headings, and 24-point type for text. Never use type smaller than 18

point for any reason.

·Make effective use of underlines and boldface.

·Use graphs and figures whenever possible.

·Make your poster visually pleasing and attractive.

·Include your presentation number in a large font on your poster so attendees can easily locate your abstract.

 

BEST POSTER AWARDS:

Best Poster Awards will be awarded in the amount of $1,000 each. Members of the ASCI, AAP, and APSA (including members of each Council) will judge posters on scientific novelty, quality and clarity of presentation. Awards will be presented on Sunday morning.

 

 

Hotel & Travel

The 2013 APSA and ASCI/AAP Joint Meeting will take place at:

Fairmont Chicago
200 N. Columbus Drive
Chicago, Illinois 60601

Phone: +1-800-526-2008 or +1-312-565-8000
Fax: +1-312-861-3656
E-mail: chicago@fairmont.com
www.fairmont.com/chicago

APSA and ASCI/AAP 2013 Joint Meeting attendees may take advantage of discounted rates at the Fairmont Chicago.

Rates if booked prior to Friday, March 29, are:

$270 for city view single/double occupancy
$320 lake view single/double occupancy*
$400 for one bedroom city view suite
$450 for one bedroom lake view suite*

*Each extra person sharing a room will be charged an additional $25 per night.

All rates are subject to state and city taxes. To reserve a room online, go to https://resweb.passkey.com/go/asciaap2013, or call The Fairmont Chicago and mention the ASCI/AAP Joint Meeting to receive the discounted rate. Reservations received on or after Friday, March 29, will be on a space and rate available basis.

A limited number of rooms are available at government rates on a first-come, first-served basis. Go to: https://resweb.passkey.com/go/asciappgovt2013 to reserve your room at the government rate. Government credentials are required at check-in.

A limited number of rooms are available at a discounted rate of $169. Please contact Steven Back (stevenback@gmail.com) for more information.

Room Reservation Deposit/Cancellation

All reservations require one night’s deposit or credit card guarantee, including 15.4 percent occupancy tax. Failure to cancel your reservation 48 hours prior to arrival will result in one night’s room and tax being charged to your credit card.

Air Travel Discounts

Airline reservations may be made through FCm Travel Solutions, the preferred agency for ASCI/AAP Joint Meeting. FCm charges a processing fee on transactions but provides a discount to all Joint Meeting attendees. International callers and callers in the state of Illinois call FCm Travel Solutions at +1-847-948-9111, ext. 3; all other callers from North America dial +1-866-341-7672.

Registration Information

Two Ways to Register

1. Online
Register via the secure APSA website. Online payment is by credit card (Visa, Master Card, American Express, Diner's or Discover, in US Dollars only).

2. Mail
Send the registration form with check to:

APSA 9th Annual Meeting Registration
111 Deer Lake Road, Suite 100
Deerfield, IL 60015 USA

Payment by check must be drawn on a U.S. bank, made payable to the American Physician Scientists Association or APSA.

Credit cards accepted: Visa, Master Card, American Express or Discover, in US Dollars only.

Registration Fees

On or before April 11: APSA Members: $50 APSA Nonmembers: $250

Note: Saturday dinner tickets are $35/person (limited seating; first come-first served).

Onsite Registration Fees

On April 26: APSA Members and APSA Nonmembers: $300

Note: Saturday dinner tickets may be available onsite at $35/person

Online Registration Closes: April 24, 2013

Payment Instructions

Registrations must include payment by check (drawn on a U.S. bank), or credit card. APSA cannot accept registrations by telephone. APSA will not accept registrations without full payment. Caution: If you submit your registration form more than once, it may result in a duplicate charge to your credit card. Complete your registration using only one method of payment.

Registration Cancellation Policy

A full refund of the registration fee or meal ticket (less an administrative fee) will be granted for all written requests received at least 30 days prior to the APSA Annual Meeting. No refunds will be made for cancellations received after this date.

The administrative fee is as follows:
APSA Member Registrations - $15 per registration
Non-member Registrations - $25 per registration
APSA Dinner Ticket - $10 per ticket
APSA Mentorship Breakfast Ticket - $5 per ticket

Telephone cancellations will not be accepted.

Cancellations may be sent via email to meetings@physicianscientists.org. The American Physician Scientists Association reserves the right to cancel any program and assumes no responsibility for personal expenses. All refunds are processed within 30 days of written cancellation notice.

Featured APSA Speakers

Debra Houry, MD, MPH

Dr. Deb Houry is Vice Chair for Research and an associate professor in the department of emergency medicine at Emory University School of Medicine. In addition, she is an associate professor in the department of behavioral science and health education and the department of environmental and occupational health at the Rollins School of Public Health. Dr. Houry is the director of the Center for Injury Control; one of 11 CDC funded Injury Control Research Centers. Her primary research interests are in the prevention of violence against women, mental health issues related to violence, and emergency care. Dr. Houry has been the recipient of numerous national awards, including the Jay Drotman Award, which is given annually by the American Public Health Association for the most outstanding young public health professional in the country (2002).

Jonathan A. Epstein, MD

Dr. Jonathan A. Epstein is the William Wikoff Smith Professor of Cardiovascular Research in the department of medicine at the Perelman School of Medicine at the University of Pennsylvania. Dr. Epstein serves as the scientific director for the cardiovascular institute and as the chair for the department of Cell and Developmental Biology Perelman School of Medicine at the University of Pennsylvania. Dr. Epstein’s lab studies the molecular mechanisms of neural crest and cardiac development, with a particular interest in applying lessons learned from developmental models to the understanding and therapy of adult diseases. Dr. Epstein is recognized internationally as a leading authority in cardiovascular development and the molecular and genetic basis of congenital heart disease. In addition, Dr. Epstein formerly served as the director of the Physician-Scientist training program at the University of Pennsylvania School of Medicine.

 

Levi A. Garraway, MD, PhD

 

 

Dr. Garraway is an assistant professor in the Department of Medicine at Harvard Medical School, as well as an assistant professor of Medicine, Medical Oncology Service, at the Dana-Farber Cancer Institute. Dr. Garraway's research is focused on genomic and functional approaches to the characterization of human solid tumors, with a special interest towards melanoma and prostate cancer. Dr. Garraway's research program utilizes both a computational, as well as an experimental approach to identify target genes and pathways that are altered by these malignancies. Dr. Garraway is the recipient of a plethora of awards and honors including the Minority Scholar Award from the American Association for Cancer Research, as well as the prestigious New Innovator Award from the National Institute of Health, which is presented to the top 29 scientists, from a little more than 2,000 applicants nationwide.

 

Shannon C. Kenney, MD

Dr. Shannon C. Kenney is the Wattawa Bascom professor in Cancer Research in the department of oncology and medicine at the University of Wisconsin-Madison School of Medicine and Public Health. Her primary research interests are in understanding the molecular regulation and pathogenesis of the human herpesvirus, Epstein-Barr virus (EBV). In addition, Dr. Kenney is a practicing infectious disease specialist with over 29 years of medical experience.

Matthew Lewin, MD, PhD

Dr. Matthew Lewin is the director at the Center for Exploration and Travel Health and a fellow of the California Academy of Sciences and the American College of Emergency Physicians. Dr. Lewin is an internationally renowned physician in emergency medicine and wilderness medicine. He has served as the physician on explorations sponsored by the American Museum of Natural History, the Field Museum, Kellogg Foundation, and National Geographic. Dr. Lewin was the director of Emergency medicine Research at UCSF from 2003 until 2009. In addition to these multitudes of roles, Dr. Lewin has given lectures about his research and clinical interests in wilderness and pre-hospital medicine at numerous national and international meetings. Please visit this link for an article on Dr. Lewin: http://www.nature.com/news/2010/100630/pdf/466022a.pdf.

Vivian Lee, MBA, MD, PhD

Dr. Vivian Lee is the Senior Vice President for Health Sciences at the University of Utah, Dean of the University's School of Medicine, and CEO of the University of Utah Health Care. She is a radiologist by training and her research explores the development of quantitative functional MRI. She has received numerous honors and awards including but by no means limited to: Outstanding Teacher Award from the International Society for Magnetic Resonance in Medicine in 2005, 2011, and 2012, the Chang-Lin Tien Education Leadership Award, Polytechnic-NYU Innovator's Award, Dynamic Achiever Award Overseas Chinese Association, and Pathfinder Award SLC Chamber of Commerce, in addition to being named one of New York's Rising Stars by Crain's New York Business Magazine.

 

Agenda Highlights

Women in Medicine Panel

Friday April 26th, 2013 – 2:00–3:00 pm

With all their responsibilities -- research, clinic, grant writing…how do physician-scientists balance their lives? What are some of the issues that women in medicine face today? The panelists of Women in Medicine will tell us how they manage the challenges in their careers, while at the same time, maintain healthy lifestyles outside of work.

Moderator: Jill Baren, MD (Chair, Department of Emergency Medicine; Chief, Emergency Services, UPHS; Professor of Emergency Medicine and Pediatrics at the Perelman School of Medicine)

Panelists:

Gail Tomlinson, MD, PhD (Director, Division of Pediatric Hematology-Oncology; Professor of Pediatrics; Distinguished Chair in Genetics of Cancer at the University of Texas Medical School at San Antonio)

Juliane Bubeck Wardenburg, MD, PhD (Assistant Professor of Pediatrics at the University of Chicago School of Medicine)

Melanie Thomas, MD, MS (Associate Director of Clinical Investigations, Chair in Medical Oncology, Associate Professor of Medicine at the Medical University of South Carolina College of Medicine)

 

Writing for Basic Science and Clinical Journals

Saturday, April 27th, 2013 – 1:30-2:15 pm

Hear from the editors themselves about how to write articles. This year's panel will feature Howard Rockman, editor of the Journal of Clinical Investigation (JCI), and Howard Bauchner, editor of the Journal of the American Medical Association.

Moderator: David Markovitz, MD (Professor of Internal Medicine in the Division of Infectious Diseases at the University of Michigan)

Panelists:

Howard Rockman, MD (Editor-in-Chief, JCI)

Howard Bauchner, MD (Editor-in-Chief, JAMA)

 

 

Residency 101

Saturday, April 27th, 2013 – 1:30-2:15 pm

This panel of residents has all the answers. Ok, maybe not. But, they certainly do know what it is like to apply to programs, interview, and contend with the match. So as you think about residency programs, whether you are just beginning to do research or are in the midst of developing your applications - come and talk with the experts!

Moderator: Michael (Kerry) O'Banion, MD, PhD (Professor and Associate Chair in the Department of Neurobiology and Anatomy; Director of the MSTP at the University of Rochester School of Medicine)

Panelists:

Dave Scoville, MD, PhD (Resident, Stanford Integrated Cardiothoracic Surgery)

Nicole Grieselhuber, MD, PhD (Resident Internal Medicine PGY1, The Ohio State University Internal Medicine)

James Liao, MD (Professor of Medicine; Section Chief, Cardiology; Director of the Physician Scientist Development Program in the Department of Medicine at the University of Chicago)

 

 

 

 

Policies Governing Bench to Bedside, Insights into Translational Research

Saturday, April 27, 2013 - 2:30-3:15 pm

Every year, physicians and physician scientists confront challenges in inadequate science/clinical research resources, insufficient funding, barriers to pursuing important research disciplines, liability, and mounting administrative burdens. More and more, physicians and physician scientists realize that involvement in the political process is a necessity if progress is to be made in these areas. Further, crucial work led by physician scientists includes translational research. However, translational research is difficult to perform, with a high failure rate. Insights from those who have successfully traversed this gap, as well as understanding how novel therapies are implemented into patient care systems, will hopefully help future physician scientists in an area that physician scientists are poised to tackle.


Our policy session entitled Physician Scientists in Policy and Advocacy: "Policies Governing Bench to Bedside, Insights into Translational Research" will provide physician scientists and trainees with information on: a) how to get involved with translational medical and science advocacy/policy; b) how the government agencies play a role in promoting translational research and implementation into patient care and; c) understand steps in the drug/therapeutics approval process, challenges and key factors helpful in the process.

 

 

Moderator: Barry Coller, MD (Physician in Chief, Vice President of Medical Affairs, Rockefeller University) & Jennifer Kwan, MD/PhD Trainee, University of Illinois Chicago

Panelists:

Mike Bristow, MD, PhD (Professor of Medicine, Cardiology Division, University of Colorado)

Anada Chakrabarty, PhD (Distinguished Professor, University of Illinois, Chicago)

Francis Collins, MD, PhD (Director of the NIH)

 

 

 

 

Post-grad Opportunities Panel

Sunday, April 28th, 2013 – 12:00-1:00 pm

In addition to being a PI of a lab – what other opportunities are out there for physician-scientists? The purpose of this panel is to allow attendees to hear about the experiences of physician-scientists who have successful careers in industry, government, and academia.

Moderator:Lawrence (Skip) Brass, MD, PhD (Professor of Medicine and Pharmacology; Director, MSTP Program at the Perelman School of Medicine)

Panelists:

Sapan Desai, MD, PhD, MBA (CEO and president of Surgisphere Corporation; Fellow in vascular surgery at the University of Texas at Houston; Adjunct Assistant Professor of Surgery at Duke University)

Griffin Rodgers, MD (Director, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK))

Dianna Milewicz, MD, PhD (Professor and Vice Chairman of the Department of Internal Medicine; Director, MD/PhD Program; Co-Director, Biomedical Engineering Center at the University of Texas Medical School at Houston)

 

 

Residency Luncheon

Sunday, April 28th, 2013 – 1:00-2:30 pm

The Residency Luncheon is arguably one of the most valuable perks offered to APSA members. It is a chance to interact with residency program directors from across the country and learn more about their programs and what they have to offer to physician scientists in training.

On behalf of the American Physician Scientists Association (APSA), a student-driven organization geared towards career development and community-building of physician-scientists in training, it is our pleasure and deep privilege to invite you or any of your program members to represent your residency programs for MD/PhD students at our 9th Annual Meeting Residency Luncheon on:

Sunday, April 28, 2013
12:30 – 2:30 pm
Fairmont Chicago, Millennium Park
Chicago, IL

If you are unable to attend the meeting in person, we offer alternatives to represent your program in your absence (please read below).

Our Annual Meeting is held jointly with the American Society for Clinical Investigation (ASCI) and the Association of American Physicians (AAP) Joint Annual Meeting. Last year, we had 300+ registrants for the APSA meeting and approximately 500 registrants for the Joint Meeting. We anticipate 350 students will attend the 2013 meeting. This represents a unique opportunity to address a national cross-section of future physician-scientists and potential future applicants to your program. In fact, the luncheon was the top-rated event in last year’s program by our attendees.

While reviewing the Residency Luncheon Packages below, please keep in mind that APSA is a fully student-run organization with a limited budget. Besides serving as a mentor during the Residency Luncheon, we offer opportunities to advertise your program to our participants in a variety of ways. These range from setting up a booth in the meeting room on Sunday, to placing your program information into every registration package, and to becoming an official APSA 2013 meeting sponsor with exposure on our website. We offer these options even if you cannot personally attend the meeting. If this is something you are interested in, please visit the link below directing you to the APSA Sponsorship Form.

If you and some of your current residents are interested in attending the residency luncheon at the upcoming APSA meeting, please complete the form and we can make the appropriate arrangements.

We also invite you advertise your residency program on our website or in our digital quarterly newsletter. By advertising in these mediums, your program will be visible to a large audience with specific interests in training as a physician-scientist. Furthermore, if you choose to participate in the residency luncheon as well as advertise on our website or in our newsletter, you will receive a 10% discount on all website/newsletter advertisements.

We look forward to seeing you in Chicago and thank you in advance for helping to make our 9th Annual Meeting a great success!

APSA Annual Meeting Residency Luncheon Packages

Item Cost
Residency Luncheon Package Level 1
Space to setup a booth at the APSA Annual Meeting
$500.00
Residency Luncheon Package Level 2
Space to setup a booth at the APSA Annual MeetingInformational handouts placed inside of APSA Annual Meetingregistration packets
$750.00
Residency Luncheon Package Level 3
Space to setup a booth at the APSA Annual MeetingInformational handouts placed inside of APSA Annual Meeting registration packets
Official Sponsor of the APSA Annual Meeting with mention at closing
$1000.00
*If you decide to only serve as a mentor during the Residency Luncheon, please be advised that we ask for a $100 to offset the luncheon costs.
Mentor Luncheon ONLY $100.00

 

Programs Attending:

1. Cincinnati Children's PSTP

2. National Institutes of Health (NIH)

3. Northwestern PSTP

4. The Ohio State Internal Medicine

5. University of Chicago Pathology

6. University of Chicago PSDP

7. University of Rochester Research Residency Track

8. Vanderbilt PSTP

9. University of Iowa PSTP

10. University of Texas Southwestern PSTP

11. Yale PSTP

12. University of Southern California Children’s Hospital Los Angeles’ Donnell Society for Physician Scientists

13. University of Minnesota PSTP

14. Oregon Health and Science University Radiation Oncology

 

Agenda

 

APSA Business Meeting Agenda

8:30 am - 8:45 am - Opening Remarks
Dania Daye, MD/PhD Candidate, University of Pennsylvania

8:45 am - 9:30 am - APSA Standing Committee Reports
Policy, Finance, Public Relations, Membership, and Events

9:30 am - 10:00 am - APSA Executive Council Candidate Speeches & Voting

10:00 am - 11:00 am - External Collaborator’s Presentations
10:00 am - 10:10 am - ACTS: Association for Clinical and Translational Science
Barry Coller, MD
10:10 am - 10:20 am - ACEP: American College of Emergency Physicians
Amy Kaji, MD PhD
10:20 am - 10:30 am - AMA WPC: American Medical Association Women Physicians Congress
Neelum Aggarwal, MD
10:30 am - 10:40 am - AMWA: American Medical Women’s Association
Jackie Wong
10:40 am - 10:50 am - ANA: American Neurological Association
Dane Chetkovich, MD

11:00 am - 11:15 am - Closing Remarks
Evan Noch, President-Elect, MD/PhD Candidate, Temple University

11:15 am - 12:15 pm - Business Lunch: APSA Breakout Sessions
Hot Topics on Issues Facing Physician-Scientist Trainees

Friday, April 26

 

8:00 a.m. – 7:00 p.m.

On-Site APSA Registration

International Foyer

8:30 a.m. – 12:30 p.m.

APSA Business Meeting

Moulin Rouge Room

1:00 p.m. – 3:00 p.m.

Poster Setup

Imperial Ballroom

12:30 p.m. – 3:30 p.m.

APSA Plenary Session

Moulin Rouge Room

12:30 p.m. –
1:00 p.m.

APSA Keynote

"Public Scholarship and the Role of Scientists”

Debra Houry, MD, MPH, Emory University School of Medicine

SAEM (Society for Academic Emergency Medicine) Sponsored Talk

1:00 p.m. –
1:30 p.m.

APSA Keynote

"Cardiac Growth and Regeneration”

Jonathan Epstein, MD, Perelman School of Medicine at the University of Pennsylvania

2:00 p.m. –
3:00 p.m.

APSA Session I: Women in Medicine Panel

Moderator: Jill M. Baren, MD, Perelman School of Medicine at the University of Pennsylvania

Panelists:

Juliane Bubeck Wardenburg, MD, PhD, University of Chicago School of Medicine

Gail E. Tomlinson, MD, PhD, University of Texas Medical School at San Antonio

Melanie B. Thomas, MD, MS, Medical University of South Carolina College of Medicine

3:00 p.m. –
3:30 p.m.

APSA Keynote

"The Cancer Genome in Biology and Therapy”

Levi A. Garraway, MD, PhD, Harvard Medical School, Dana-Farber Cancer Institute

3:30 p.m. – 6:00 p.m.

Plenary Session I – Understanding Disease Mechanisms to Improve Human Health

Moderators: Warner C. Greene, Peter Tontonoz, and Taylor Heald-Sargent

3:30 p.m. –
4:00 p.m.

"Scaling Up the Potential of Clinical Research”


Francis Collins, MD, PhD, National Institutes of Health

4:00 p.m. –
4:30 p.m.

"Hepatitis C: Is the End in Sight?”


Charles Rice, PhD, Rockefeller University

4:30 p.m. –
4:45 p.m.

Presentation of Career Development Awards

4:45 p.m. –
5:15 p.m.

"Mitochondrial Protein Acylation and Metabolic Regulation”


Eric Verdin, MD, Gladstone Institute, UCSF

5:15 p.m. –
5:45 p.m.

"Induction of Pluripotency by Defined Factors”


Shinya Yamanaka, MD, PhD
2012 Nobel Prize for Medicine or Physiology

Center for iPS Cell Research and Application (CiRA), Japan, and Gladstone Institute, UCSF

5:45 p.m. –
6:00 p.m.

Q&A

7:00 p.m. – 9:00 p.m.

AAP Offsite President's Dinner (by invitation only)

Mid America Club

7:00 p.m. – 9:00 p.m.

ASCI Annual Dinner/Introduction of New Members (ticketed guests only)

"Clinical Research: The Uphill Climb”

David G. Nathan, MD, Harvard Medical School, Dana-Farber Cancer Institute

Moulin Rouge Room

7:00 p.m. – 9:00 p.m.

APSA Dinner Outing: Interest Groups
Sign up at the Meeting Registration Desk outside the International ballroom. Groups will meet by the Registration Desk at the Fairmont Hotel.

Restaurants: The Gage, Hot Woks Cool Sushi – Willis Tower, Sappori Trattoria, Gino’s East, The Purple Pig

9:00 p.m. – Midnight

APSA Welcome Reception

APSA Presidential Address


Speaker: Dania Daye, MD, PhD Candidate, HHMI-NIBIB Interfaces Scholar, University of Pennsylvania School of Medicine

Willis Tower Skydeck (99th Floor)

Saturday, April 27

7:00 a.m. – 5:00 p.m.

On-Site APSA Registration

International Foyer

7:00 a.m. – 8:15 a.m.

Young Investigators Mentoring Breakfast (ticket required)

Sign up at the Meeting Registration Desk outside the International Ballroom

Moulin Rouge Room

8:15 a.m. – 11:15 a.m.

Plenary Session II – Understanding Disease Mechanisms to Improve Human Health

Moderators: J. Larry Jameson, William C. Hahn, and Dania Daye

International Ballroom

8:15 a.m. –
8:45 a.m.

"Reflections of a Former MSTP Director on Physician/Scientist Training”


Kevin Shannon, MD, University of California, San Francisco

8:45 a.m. –
9:15 a.m.

"Developing New Prostate Cancer Drugs”


Charles Sawyers, MD, Memorial Sloan-Kettering Cancer Center

9:15 a.m. – 9:30 a.m.

APSA Oral Abstract Presentation

"Role of FRS2 and FGF/FGFR Autocrine Signaling in the Proliferation of Ovarian Cancer Cells”

Leo Y. Luo, BS, Broad Institute of Harvard and MIT

9:30 a.m. – 10:00 a.m.

"Direct Cardiac Reprogramming: From Developmental Biology to Regeneration”

Deepak Srivastava, MD. Gladstone Institute, UCSF

10:00 a.m. – 10:30 a.m.

Break

10:30 a.m. –
11:00 a.m.

"Novel Mechanisms by Which Adipose Tissue Regulates Systemic Insulin Sensitivity and the Risk for Diabetes”


Barbara Kahn, MD, Harvard Medical School, Beth Israel Deaconess Medical Center

11:00 a.m. – 11:15 a.m.

APSA Oral Abstract Presentation

"Heat Shock Protein 70 Demonstrates IL-10 Mediated Immune Modulation in Experimental Colitis”

InYoung Kim, PhD, University of Chicago

11:15 a.m. –
11:45 a.m.

"Unifying Role for Prions in Degenerative Diseases”

Stanley Prusiner, MD, University of California San Francisco

11:45 a.m. – 1:30 p.m.

Poster Session with Lunch

Imperial Ballroom

1:30 p.m. – 2:00 p.m.

Poster Dismantle

1:30 p.m. – 3:00 p.m.

ASCI and AAP New Member Presentations

International Ballroom

1:30 p.m. – 1:50 p.m.

"Telomerase and Idiopathic Pulmonary Fibrosis”

Mary Armanios, MD (New ASCI Member), Johns Hopkins University School of Medicine

1:50 p.m. – 2:10 p.m.

"VEGF and the Glomerular Barrier – Two Sides to the Story”

Susan Quaggin, MD (New AAP Member), Northwestern University

2:10 p.m. – 2:30 p.m.

"Regulation of the Dendritic Cell and Macrophage Lineage”

Miriam Merad, MD, PhD (New ASCI Member), Mount Sinai School of Medicine

2:30 p.m. – 2:50 p.m.

"Treating the Untreatable: An Exome Sequencing Approach in Neurodevelopmental Disease”

Joseph Gleeson, MD (New AAP Member), University of California, San Diego

3:30 p.m. – 3:50 p.m.

"Mapping the Origins of Cancer”

Richard James Gilbertson, MD, PhD (New ASCI Member), St. Jude Children’s Research Hospital

3:50 p.m. – 4:10 p.m.

"The Search for Disease Genes: What Mendel Can Tell us About Medicine”

David Valle, MD (New AAP Member), Johns Hopkins University School of Medicine

1:30 p.m. – 2:15 p.m.

APSA Breakout Sessions:

Residency 101

Moderator:M. Kerry O’Banion, MD, PhD, University of Rochester

Panelists:

James K. Liao, MD, University of Chicago

Nicole Grieselhuber, MD, PhD, The Ohio State University

David Scoville, MS, MD, PhD, Stanford Integrated Cardiothoracic Surgery

Gold Room

Writing for Basic Science and Clinical Journals

Moderator: David Markovitz, MD, University of Michigan

Panelists:

Howard A. Rockman, MD (Editor-in-Chief, JCI)

Howard C. Bauchner, MD (Editor-in-Chief, JAMA)

Crystal Room

2:30 p.m. – 3:15 p.m.

APSA Policy Panel

Moderator: Barry S. Coller, MD, Rockefeller University & Jennifer Kwan, MD/PhD Trainee, University of Illinois, Chicago

Panelists:

Francis S. Collins, MD, PhD, National Institutes of Health

Michael R. Bristow, MD, PhD, University of Colorado

Ananda M. Chakrabarty, PhD, University of Illinois, Chicago

Gold Room

3:00 p.m. – 3:30 p.m.

Break

International Ballroom Foyer

4:10 p.m. – 4:45 p.m.

APSA Keynote

"Epstein-Barr virus: From Bench to Bedside”

Shannon Kenney, MD

University of Wisconsin-Madison School of Medicine and Public Health

IDSA (Infectious Disease Society of America) Sponsored Talk

International Ballroom

4:45 p.m. – 5:00 p.m.

APSA Oral Abstract Presentation

"T-bet Dictates CD8+ T Cell Tolerance Versus Immunity Following Antigen Recognition”

Stephanie R. Jackson, BSE, MS, Saint Louis University School of Medicine

5:00 p.m. – 5:30 p.m.

AAP Presidential Address:

"Seeking Sustainable Solutions to Global Health Challenges: No More Band-Aids”

Warner Greene, MD, PhD
Gladstone Institute, University of California, San Francisco

5:30 p.m. – 6:00 p.m.

ASCI Presidential Address:

"The Perfect Storm: Challenges and Opportunities for Translational Research

William C. Hahn, MD, PhD
Harvard Medical School, Dana-Farber Cancer Institute

7:30 p.m. – 9:00 p.m.

APSA Dinner (ticket required – black tie optional)

"Don’t get bit: How expeditions drive clinical research”

Speaker: Matthew Lewin, MD, PhD, FACEP, Center for Exploration and Travel Health, California Academy of Sciences

Moulin Rouge Room

9:00 p.m. – 10:00 p.m.

APSA dinner attendees join AAP members for dinner speaker

"A Funny Thing Happened on the Way to Stockholm”

Robert Lefkowitz, MD, Duke University

10:00 p.m. – Midnight

Dessert Reception (open to all attendees)

Imperial Ballroom Foyer

Sunday, April 28

7:00 a.m. – 8:15 a.m.

Young Investigators Mentoring Breakfast (ticket required)

Sign up at the Meeting Registration Desk outside the International Ballroom

Moulin Rouge Room

8:15 a.m. – Noon

Plenary Session III – Understanding Disease Mechanisms to Improve Human Health

Moderators: Warner C. Greene, William C. Hahn, and Katherine Hartmann

International Ballroom

8:20 a.m. – 8:30 a.m.

AAP Business Meeting

8:20 a.m. – 8:30 a.m.

Best Poster Award Presentation

8:30 a.m. – 9:15 a.m.

Kober Medal Presentation & Lecture

Recipient: John T. Potts, Jr., MD
Massachusetts General Hospital

Presenter: J. Larry Jameson
Perelman School of Medicine,
University of Pennsylvania

9:15 a.m. – 10:00 a.m.

ASCI/Stanley J. Korsmeyer Award Lecture

Bruce Beutler, MD, UT Southwestern Medical Center

10:00 a.m. – 10:45 a.m.

"Targeting the Gut to Treat the Heart”

Stanley Hazen, MD, PhD, Cleveland Clinic

10:45 a.m. – 11:15 a.m.

APSA Oral Abstract Presentation

"Systemic Type I Interferons Indirectly Promote Epithelial Proliferation and Turnover”

Lulu Sun, BSc, Washington University in Saint Louis University School of Medicine

International Ballroom

11:15 a.m. – Noon

APSA Keynote

"MRI: From Science to Society”

Vivian S. Lee, MD, PhD, MBA, University of Utah

RSNA (Radiological Society of North America) Sponsored Talk

Noon – 1:00 p.m.

APSA Session - Post Graduate Opportunities Panel

Moderator:Lawrence (Skip) Brass, MD, PhD, Perelman School of Medicine, University of Pennsylvania

Panelists:

Sapan S. Desai, MD, PhD, MBA, CEO and President Surgisphere Corporation, University of Texas at Houston; Duke University

Dianna M. Milewics, MD, PhD, University of Texas Medical School at Houston

Griffin P. Rodgers, MD, PhD, MBA, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

International Ballroom

1:00 p.m. – 2:30 p.m.

APSA Residency Luncheon

1. Cincinnati Children's PSTP

2. National Institutes of Health (NIH)

3. Northwestern PSTP

4. The Ohio State Internal Medicine

5. University of Chicago Pathology

6. University of Chicago PSDP

7. University of Rochester Research Residency Track

8. Vanderbilt PSTP

9. University of Iowa PSTP

10. University of Texas Southwestern PSTP

11. Yale PSTP

12. University of Southern California Children’s Hospital Los Angeles’ Donnell Society for Physician Scientists

13. University of Minnesota PSTP

14. Oregon Health and Science University Radiation Oncology

Moulin Rouge Room

2:30 p.m. – 3:30 p.m.

APSA Executive Council Meeting (All newly elected members must attend)

Gold Room

Contact us with questions about the Annual Meeting

Abstract Submission

The abstract submission for the APSA/ASCI/AAP Joint Meeting is now closed.

The 9th APSA Annual Meeting will take place in Chicago on April 26-28, 2013 and will include, among other events, a poster session. APSA, ASCI, and AAP will once again offer 50+ travel awards for the best abstracts submitted and APSA will be sponsoring three $1,000 awards for the best posters presented at the meeting.

Congratulations to this year's Travel Award Winners:

 

2013 ASCI/AAP Joint Meeting Travel Award Recipients

Leo Y. Luo

Broad Institute of Harvard and MIT

Feras Akbik

Yale University

Joseph L. Alge

Medical University of South Carolina

Neal Amin

Salk Institute

Vafa Bayat

Baylor College of Medicine

Lauren K. Brady

University of Pennsylvania

Ryan A. Denu

University of Wisconsin-Madison

Matthew L. Hedberg

University of Pittsburgh

Annie L. Hsieh

Johns Hopkins University

 

Tiffany Y. Hsu

Baylor College of Medicine

Rajan Jain

University of Pennsylvania

Jiyeon S. Kim

University of Pennsylvania

Nicholas O. Markham

Vanderbilt University

Kyle W. McCracken

University of Cincinnati/Children's Hospital

Brian D. Muegge

Washington University School of Medicine

Pankaj Pal

Washington University in St. Louis

Warren W. Pan

University of Michigan

Tyler P. Rasmussen

University of Iowa

Cecinio C. Ronquillo

John A. Moran Eye Center, University of Utah

Marc S. Sherman

Washington University in St. Louis

Jane W. Symington

Washington University in St. Louis

Maria C. Trissal

Washington University in St. Louis

Christine L. Tung

University of California San Diego

Samuel E. Vaughn

Cincinnati Children's Hospital and Medical Center

Yanjia J. Zhang

Harvard School of Public Health

 

 

2013APSA Annual Meeting Travel Award Recipients

Stephanie R. Jackson

Saint Louis University School of Medicine

InYoung Kim

University of Chicago

Samuel D. Quaynor

Georgia Health Sciences University

Lulu Sun

Washington University in St. Louis

Christopher O. Audu

Dartmouth

Kristen A. Batich

Duke University

Douglas M. Bennion

University of Florida

Sonali J. Bracken

University of Connecticut Health Center

Andres Chang

University of Kentucky

Irene Chernova

University of Pennsylvania

Stephen M. Chrzanowski

University of Florida

Dania Daye

Perelman School of Medicine at the University of Pennsylvania

Adam C. Diehl

Johns Hopkins University

Sarah E. Greene

Washington University in St. Louis

Brittany L. Gregory

University of Pennsylvania

Emily N. Guhl

University of Chicago

Bianca N. Islam

Georgia Health Sciences University

Katherine L. Knorr

Mayo Clinic

Amy J. Reid

University of Texas Medical School at Houston

Michael J. Ripple

Louisiana State University Health Sciences Center

Casey S. Seldon

Georgia State University

Josephine W. Thinwa

University of Texas Health Science Center San Antonio

Ting-Lin Yang

University of Pennsylvania

Wan R. Yang

Johns Hopkins University

Tresa E. Zacharias

University of Texas Southwestern Medical Center

Financial Support

The American Physician Scientists Association would like to gratefully thank the following funds, programs, corporations, and organizations for their financial support for APSA's 9th Annual Meeting in Chicago, IL.

National Cancer Institute (NCI)
National Institutes of Health (NIH)

National Institutes of Health Logo

Funding for this conference was made possible (in part) by 5 R13 CA136301-03 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

AM Updates

The 2013 APSA Annual Meeting has concluded!. Keep checking this page for updates, highlights, and photos from the meeting. Thanks to everyone who joined us in Chicago! See you next year!

We'd love to see any pictures you've taken at the meeting. Please share them with us on our Facebookpage.


Day 3: April 28th

Afternoon Sessions - Post-Grad Panel and Residency Luncheon

Post Graduate Opportunities PanelFollowing the last plenary speaker, the APSA Post-Graduate Opportunities Panel convened. Moderated by Lawrence Brass, MD, PhD and Director of the MSTP at UPenn, the panel featured Sapan Desai, MD, PhD, MBA; Griffin Rodgers, MD, PhD, MBA, Director of the National Institute of Diabetes, Digestive, and Kidney Diseases; and Dianna Milewicz, MD, PhD, Director of the MD/PhD Program at the University opf Texas Health Science Center at Houston and M.D. Anderson Cancer Center. The panelists shared their own career stories and spoke of how trainees can navigate the post-graduate years. Dr. Brass spoke first and encouraged MD/PhD students to learn how to be adaptable to change and pursue outcomes-driven work in academia, research institutes, and/or industry. His advice cautions students against being too rigidely bound to a single career path.

Speaking next, Dr. Desai described his ventures into the world of business and medicine. The CEO and President of Surgisphere Corporation, he encouraged dual degree students to look into business training, such as online MBA program options, to learn how to speak the language of business. He is passionate about medical textbooks and finds much to fault in many current textbooks. Rather than complain, he took his business acumen and started a company that publishes books and journals. He co-wrote a book on vascular surgery that is today used by those studying for the vascular surgery boards. A journal he initiated, the Journal of Surgical Radiology, is growing fast, utilizing a multidisciplinary and technically focused approach that Those interested in business should pay attention to Dr. Desai's examples.

Residency LuncheonDr. Rodgers followed, relaying the perspective of an NIH director. He moved into the NIH after his training expecting to stay a short time and then move on. He never imagined he would remain long in his position, let alone rise to lead the organization. He shared ten tips for success with trainees that he had garnered from many training sessions with leading NIDDK researchers. Look for all of his tips in the video to be posted soon!

The final panelist, Dr. Milewicz, outlined the pros and cons of an academic medical career. She stressed the positive benefits of research autonomy, mentoring opportinities, and the ability to travel for your science in the academic world. However, she cautioned trainees to keep well in mind some of the pitfalls, including the challenges of balancing research, clinical, and teaching workloads; the pressure for research productivity; and university political wrangling.

At the conclusion of the panel, trainees made their way to the Moulin Rouge room for a residency luncheon with residency programs that court the physician-scientist. Many programs were represented, from the NIH to the University of Chicago to the University of Sourther California Children's Hospital. Trainees rotated between tables, learning about each program and getting to know the directors to whom they may someday soon (yes, even six, seven, or eight years is soon!) be sending applications. For those who could not make the AM this year, you missed out!

Plenary Session 3 - Morning Sessions

John T. Potts, JrThe morning sessions began with presentations of best poster awards. Check back soon for the names and photos of the awardees. Following these awards, presentation of the Kober medal, the most prestigious award of the AAP to honor a distinguished physician-scientist. This year's recipient is John T. Potts, Jr, MD, former chair of medicine at Massachussetts General Hospital, promiment endocrinologist, and a major figure in the field of bone and calcium biology. He has been an important mentor to many generations of physician-scientists, including J. Larry Jameson, MD, PhD, executive vice president of the University of Pennsylvania for the Health System and dean of Penn’s School of Medicine, who introduced him. His career has been marked by collaborative efforts long before such was in vogue. The final words of his acceptance speech were directed at the many mentors in the audience. He exhorted mentors to be active in mentoring, seeking out junior physician-scientists who need guidance, actively taking a role in their success, and ensuring they follow-up to see how their mentee is faring. Dr. Potts' success, and the success of his many trainees, speak to the wisdom of his words.

Bruce BeutlerThe ASCI/Stanely J. Korsmeyer was given by Bruce Beutler, MD, innate immunity pioneer and recipient of the 2011 Nobel Prize in Physiology or Medicine. He spoke extensively of the power of genetics to unravel the nature of biological systems. For many years, he and his group have been inducing mutations in mice and examining the phenotype of those mice, working backwards to determine the causative mutation when a phenotype arises. He compared this work to deciphering the many pieces of a Swiss watch. Each works intimately with all the others to make the watch work. We cannot hope to understand the watch, or the immune system, by examining its whole; we must instead look to its parts.

Dr. Beutler described his approach as unbiased, relying not on hypotheses and biases inherent in hypotheses to determine the direction of his science. Instead, he lets the phenotypic changes and discovered mutations drive his work. Interestingly, one member of the audience spoke during his Q&A session, challenging the assertion that an unbiased approach is the best. The questioner suggested that there must be bias in the system, bias arising from concern for the patient, and without this bias toward one idea or another much of the passion in trainees will be lost. We may yet see these two viewpoints in a dueling JCI editorial.

Stanley HazenStanley Hazen, MD, PhD spoke next of his work on the gut microbiome and its affects on cardiovascular health. Gut microbiota can act on food that is ingested and turn it into different products. This is not as new concept; however, what Dr. Hazen describes is a pathway that begins with the carnitine in red meat and energy drinks and ends with trimethylamine oxide, or TMAO, a compound he and others link to atheroscelerosis and vascular heart disease. In his studies, your diet influences TMAO production and subsequent risk. In vegans and vegetarians, ingestion of carnitine does not lead to an appreciable TMAO rise, suggesting the gut microbiome has adapted to a low-carnitine environment and has shifted away from its production. By contrast, an omnivorous individual produces much TMAO after carnitine consumption. Further linkage comes from antibiotic studies, where he and his group wiped out the gut microflora with an antibiotic cocktail and noted that TMAO production in omnivorous individuals matched the vegans. As the saying goes, you are what you eat, and he hopes to be able to target the gut microbiome to change this process and allow people to eat the foods they want while avoiding risky complications. These results, and others, appear in a recent edition of Nature Medicine.

Following Dr. Hazan's work, Lulu Sun, MSTP candidate at the University of Washington in Saint Louis, presented her work detailing the role of type 1 interferon in promoting epithelial proliferation and turnover, suggesting a link between interferons, macrophages, and the proper homeostatic maintenance of epithelial barriers. Samuel D. Quaynor, MD/PhD student at Georgia Health Sciences University, next presented his investigation of a molecule involved in the migration of GnRH neurons during development, NELF. His data in knockout mice suggest that NELF may play a role in the pathogenesis of Kallman syndrome, a disease arising from defective migration of GnRH neurons.

Vivian LeeThe final APSA keynote of the morning, and the final lecture of the morning, was given by Vivian Lee, MD, PhD, MBA, Dean of the University of Utah School of Medicine and CEO of Utah Health Systems. A radiologist and radiological researcher, Dr. Lee spoke of the power of imaging for medical research and patient care. The benefits are clear, and she presented many, but she also spoke of the limitations. In particular, she wondered whether the radiology community has been remiss in determining if its imaging studies provide real benefit to patient care. Thus far, she fears not, and finds much work to be done before we can believe that doing this or that imaging study is truly the most cost-effective and clinically-relevant course of action. She used this analysis to raise challenging questions and proposed three main avehnues by which physician scientists can contribute to improving medical care which utilizes imaging technology: 1. Develop great technologies; 2. Advance scientific knowledge; and 3. Ask the right questions. This advice applies far beyong radiology.

Day 2: April 27th

Afternoon Sessions - Breakout Sessions

Writing for Basic Science and Clinical Journals Dr. Howard Rockman, Editor-in-Chief of the Journal of Clinical Investigation (JCI), gave a brief presentation. The JCI primarily publishes basic science research, receiving almost 5000 submissions per year. It rejects 70% of submitted works before they ever see a reviewer and only accepts papers that take their field forward significantly. Dr. Rockman shared several key pieces of advice for writers, including:

  • Pay attention to your title title – it should capture the audience. The first word is the most important
  • The first figure should be your major discovery
  • Use an active voice in your results section
  • Don’t manipulate your data

Howard Bauchner, Editor-in-Chief of the Journal of the American Medical Association (JAMA), spoke next. JAMA primarily publishes clinical research and has a 5% acceptance rate, rejecting 60% of submissions before review. Dr. Bauchner gave helpful tips in his presentation, including the following:

  • Choose the correct journal
  • Follow the instructions
  • Make the abstract impeccable, as 90% of people read ONLY the abstract
  • Keep papers concise, especially when submitting to clinical journals
  • Your paper should have a major theme – emphasize it throughout the paper
  • Don’t circulate a draft before discussing authorship

Residency 101Residency 101 Dave Scoville, MD, PhD; James Liao, MD; Nicole Grieselhuber, MD, PhD; and Shwayta Kukreti, MD, PhD discussed their experiences applying for, entering, and continuing in residency training. Each had a wealth of advice for trainees, and a common thread was to exercise caveat emptor when choosing a residency. Ask questions of the residents, both first year and third year, to see if they are happy. Residents won't lie to you! They also stressed the importance of gauging program director and faculty interest in and support for trainees who care about research. If your dean or director cares but the faculty are cool to the idea, what happens when that director leaves a month after you arrive? However, they all affirmed that residency training is meant to be a time of clinical growth and development. Research is important, but it is your job as a resident to learn how to be a good clinician.

APSA Policy Panel Jennifer Kwan, VP for External Affairs, next convened a distinguished panel of scientists to discuss some of the most important policy issues facing trainees today. Francis Collins, MD, PhD; Michael Bristow, MD, PhD, Ananda Chakrabarty, PhD; and Barry Coller, MD, shared their thoughts on policies that could promote (or, if done incorrectly, hinder) development of translational research and the scientists who perform it.

Francis Collins, MD, PhD, Director of the NIH, discussed the Biomedical Research Workforce Working Group’s recommendations for graduate students, post-doctoral fellows, and clinician scientists. The working group has diversity initiative strategies to promote scientific endeavors among underrepresented minorities. He briefly promoted the NIH-Lasker Clinical Research Scholar Program, which is in place to assist early-stage researchers in their progression to independent scientists.

Residency 101Michael Bristow, MD, PhD, of the University of Colorado briefly defined translational research, and went on to discuss some of his own work concerning the pharmacology of beta blockers and of the adrenergic receptors. He then discussed public policies concerning translational research, stating that biomedical research is in "crisis mode," greatly in need of a large number of advocates. Dr. Bristow ended his talk on a bright note: "However, it’s not as bad as it sounds."

Ananda Chakrabarty, PhD, a microbiologist from the University of Illinois, Chicago, reminded the audience about the current Supreme Court cases (including Bowman vs. Monsanto) relating to science and research. He was party to the landmark Diamond v. Chakrabarty US Supreme Court cast which held that patenting of genetically-modified organisms was legal. He then discussed in some detail a clinical trial that is currently underway with p28, a bacterial protein with therapeutic effects against cancer. He closed by stressing that intellectual property is important and must be protected.

Barry Coller, MD, from Rockefeller University discussed his own translational research work in the field of platelet interactions and clotting disorders, and then touched on important skills required of translational researchers, which include 1) articulating a health need, 2) having the ability to create a robust, practical assay, and 3) being able to conceptually design a Phase 3 study to assess safety and efficacy. A number of national and institutional policies affect translational researchers, including NIH grant policies, board certification, patent policy, and conflict of interest.

A discussion ensued about a variety of topics, including the importance of scientific advocacy at the institutional and national level. Dr. Collins implored attendees to be advocates to their congressmen and senators about the significance of biomedical research. Multiple panelists reminded the audience that if they wanted a piece of the ever-shrinking funding pie, they must speak out. If we as trainees have ideas, we should reach out to the NIH; they really do care what we think. If we as trainees feel a pending cut is a bad idea, we should contact our congressmen and women to say why. Dr. Collins and Dr. Coller particularly stressed that personal interactions with congressmen, whether inviting them to tour your institution's research facilities or writing letters to them, has a powerful impact.

Afternoon talks Returning to the International Ballroom, we began this session with an APSA keynote by Shannon Kenney, MD, concerning her work with Epstein-Barr Virus (EBV). Her lab has primarily been focused on understanding the regulation of lytic reactivation of EBV and how converting a latent infection to the lytic form can be used to inhibit the growth of different types of EBV-associated cancers. She has discovered that multiple pathways of lytic reactivation exist, and that the viral methylation state strongly affects these pathways. Clinical studies have recently begun to investigate lytic induction as a treatment in human patients and have shown that therapies such as ganciclovir, which causes lytic induction, can be used synergistically with radiation and/or chemotherapy to improve outcomes in patients with EBV-positive cancers.

Stephanie Jackson, a student from Saint Louis University School of Medicine, gave the final APSA oral abstract presentation of the day. Her work involves the role of transcription factors such as T-bet in T cell responses to antigens. She showed that lack of T-bet expression correlates with CD8+ T cell tolerance. She also spoke of T-bet's necessity for proper cytolytic function of CD8+ T cells and for adequate effector cytokine production in a tolerizing environment. As her work demonstrates, T-bet induction may be important in the development of therapies for a number of diseases. Congratulations to Stephanie on her selection to present!

AAP Presidential AddressDr. Warner Greene, MD, PhD brought a different perspective to the conversation about translational medicine through his extensive experience in global health and health disparities, particularly in Africa. He shared with the group his personal reflections about the power of the availability of anti-retroviral clinical trial medications in the African countries his organizations service, including the problem of Mondays and Tuesdays. As Dr. Greene described it, he walked into an African infectious disease clinic one Monday to a packed but silent and forlorn waiting room, with patients saying nothing. The very next day, he returned to find the room full of lively, happy people waiting to be seen. When he asked about the difference, the reason was striking in its simplicity: those patients on Tuesday are part of a clinical trial and receive antiretroviral therapy, while those on Monday do not. Dr. Greene seeks to turn those Mondays into Tuesdays.

Dr. Greene leads the Acordia Global Health Foundation, an organization with many industrial, academic, and government partners that works to build medical service infrastructure and strengthen medical school education to solve the problem of a shortage of caregivers. Groups like Médecins Sans Frontières are a vital part of healthcare in many countries and do noble work, but those nations will never escape the need for groups like Médecins Sans Frontières unless they build up a medical infrastructure to produce healthcare workers in sufficient numbers. He has overseen or contributed to a host of initiatives worldwide, and he encouraged the audience to remember that there can be more to a physician-scientist than fancy published papers or an academic career.

Dr. William Hahn, MD, PhD gave the ASCI Presidential Address with a focus on the four ways in which senior scientists can advance the field of translational medicine. He emphasized the importance of embracing change by leading the debate and innovating whenever appropriate, insisting on excellence in research and in medical education, arguing our case by conveying to the funding institutions a clear message about our value proposition to include measuring the outcomes of our scientific efforts (echoing the policy panel!), and developing the next generation of scientists. The collaboration between APSA and ASCI in organizing meetings such as this one is a value investment in the future of our scientific discoveries and translation to clinical applications. He exhorted us to be positive and to work to do good and effect good change in the world. As Mahatma put it, and Dr. Hahn quoted, "Man often becomes what he believes himself to be. If I keep on saying to myself that I cannot do a certain thing, it is possible that I may end by really becoming incapable of doing it. On the contrary, if I have the belief that I can do it, I shall surely acquire the capacity to do it even if I may not have it at the beginning." We can become and do what we believe, so we'd better believe right.


Plenary Session 2 Highlights - Morning

Kevin ShannonThe second day began with a highly informative "State of the Programs" presentation by Dr. Kevin Shannon, former director of the MSTP at UCSF. He gave an overview of UCSF's program but included published and unpublished data from other programs. He noted that MSTP graduates end up across the spectrum of clinical specialties, although over half of graduates end up in pediatrics, internal medicine, and pathology. As Dr. Shannon put it, MSTPs are succeeding; over 2/3 of MSTP graduates end up in academia, and more still end up in areas, such as the pharmaceutical industry, that he felt were as necessary as traditional academic medicine. For his program specifically, he noted a big strength in the MSTP Council, a body made up of prominent physician-scientist faculty. UCSF MSTP students are required to choose a mentor from the council for the first two years and to include a Council member on their thesis committees. He believes that the perspective of these mentors is very important to students, particularly in resolving some of the differences that can arise when a research mentor is dealing with a very atypical graduate student, of which MSTP students are. He strongly believes that basic science training should not be compromised in a dual-degree program, and he resists the urge to shorten programs as many (including the NIH) desire.

Following Dr. Shannon, Charles Sawyers, MD, told the story of the development of a number of prostate cancer drugs. While a number of prostate cancer drugs have been highly successful, the disease has not been cured. Resistance to the drugs is the primary cause of this. It has been determined that resistance to androgen antagonists is partially mediated by the activity and expression of the glucocorticoid receptors, with other evidence suggesting androgen receptor mutations are also involved. His group studies these problems of resistance, and he believes we are on our way around the problem.

Next, one of the oral abstract presentations, from Leo Luo of the Broad Institute of Harvard and MIT, took us through his work on the role of FR52 in ovarian cancer. They have found that FRS2 is amplified in over 10% of primary ovarian cancers, acts through the MAPK pathway, and can induce transformation in cell lines. They have also found that FRS2 and FGFR amplifications are mutually exclusive. Congratulations to Leo on being awarded an oral presentation!

Deepak Srivastava, MD, brought the heart back into the meeting, speaking to us on reprogramming and differentiation within the heart. Dr. Srivastava studies cardiac fibroblasts, trying to coax these cells to become new cardiomyocyte-like cells. He suggested that this reprogramming can occur in vivo (at least in mice). As his lab moves into larger animals, he hopes these initial positive signs will translate into real hope for patients.

Following a brief break, Barbara Kahn, MD, brought us into the world of obesity and diabetes, taking us through the many lipid and metabolic pathways that wind through the two diseases. She spoke at length of RBP4, an adopokine that her lab has linked to diabetes and the cause of insulin resistance. Her group suspects inflammation is involved, and they are actively pursuing the signaling pathways involved.

Following Dr. Kahn, the second trainee oral abstract presentation was given by InYoung Kim of the University of Chicago. InYoung studies intestinal immunity and tolerance, and she took us through her work on TLR-6 and IL-10 in maintaining the balance between inappropriate inflammatory responses and inappropriate lack of inflammatory activity. She revealed a role for HSP70 in IL-10 production and subsequent modulation of inflammation. Congratulations to InYoung on her selection to present!

The final talk of the morning was given by Nobel laureate Stanley Pruisner, MD, the discoverer of prions. He spoke at length of his believe that prions underly many more diseases than previously thought, including Alzheimer disease, Huntington disease, and frontotemporal dementia. As he sees it, the key proteins of these diseases, including AB amyloid, can become a prion, feeding back on normal amyloid to produce ever-more amyloid prions. He spoke of the timing of these diseases, wondering how familial forms Poster Sessionof many of these neurological diseases, despite a clear genetic mutation acting from early life, do not appear until the fourth or fifth decade of life. As he sees it, production and clearance of the prion forms of these proteins accounts for the delay seen. While not accepted by everyone, neither was his initial work on prions. Wherever the science takes these neurological diseases, Dr. Pruisner's presentation provides much food for thought, and his story much inspiration for trainees who may be discouraged by other investigators refusing to believe their results or ideas.

Following Dr. Pruisner's talk, all convened in the Imperial Ballroom for the poster session. This year, a record 229 abstracts were selected for posters, necessitating halving the space available for each poster. Trainees of all levels shared their work with the senior physician-scientists of the ASCI and AAP, an invaluable opportunity not only to meet some of the greatest investigators in your field but also to benefit from their insights into your own work. Even our own President-Elect, Evan Noch (seen with Taylor Heald-Sargent, VP for Events), got in on the action.


Day 1: April 26th

Plenary Session I Highlights - Afternoon

Francis CollinsThe first speaker of the first plenary session, Francis Collins laid out the grim portrait of research funding today. However, while he did not give a false hope that funding levels would magically skyrocket, he spoke passionately about several key initiatives at NIH. One, the recent initiative by President Obama to devote large funds to brain research, is the kind of project Dr. Collins believes we need, a large and ambitious undertaking that will spur real advancements. He spoke of the need for new tools and new ideas, including partnership with the pharmaceutical industry. He noted the concern over falling paylines and repeated his stance that funding would be redirected from existing grants to stabilize the paylines and allow investigators more of a chance to secure funding. In response to a question from Dylan Nielson, who relayed the concerns of trainees that there would be no place for them, Dr. Collins stated that trainees are one of his top priorities, both supporting them in training and creating an environment where they can flourish after training. He mentioned that he supported raising the pay of trainees to reduce the hardship of long and expensive training periods.

Shinya YamanakaSeveral facinating speakers followed Dr. Collins, talking of issues as diverse as Hepatitis C, the regulation of mitochondrial protein acetylation and its affect on metabolism, and concluding with remarks by one of the 2012 Nobel Laureates in Medicine or Physiology, Shinya Yamanaka, MD, PhD. Dr. Yamanaka spoke at length of the promise of induced pluripotent stem cells (iPS) for toxicology screening, direct therapy such as creation of blood transfusion products from the patient's own cells, and the possibilities of banking iPS by HLA haplotype to ensure that anyone who needs iPS cells for therapy can readily find them. He described some of the research going on in his groups, including some targeting spinal cord injury. A rugby player and martial artist, Dr. Yamanaka has a great interest in the care of those with spinal cord injuries. Showing a video of a mice given such injuries, he compared one with no treatment to one given iPS cells to restore the broken neurons. That mouse, which was able to move around well compared to its paralyzed counterpark, seemed to him to be smiling at us. With all the promise of iPS cells, one cannot help but smile.

Shinya YamanakaAlso part of the afternoon was the recognition of the career development award recipients. All were called to the stage for a group photo with ASCI President-Elect Peter Tontonoz and AAP President Warner Greene. Congratulations to the winners!


APSA Plenary Session Highlights - Morning

Debra Houry, MD, MPH opened the plenary session with a new take on the role of scientists in shaping public discourse. She spoke of the great need for scientists to move beyond sharing their work with the scientific world and to move into informing the public directly. She took particular aim at the Op-Ed system, encouraging all of us to consider writing Op-Ed pieces about issues we are passionate about. If we do not, she notes, the only ones left to shape public discourse and opinion may be those who want to oppose science. Additionally, it can be a way to further one's reach and reputation. Some promotion committees now consider Op-Ed pieces as legitimate publications. In other instances, an Op-Ed or other piece in a non-traditional venue may bring great recognition. As she puts it, one piece she wrote garnered her more invitations to speak at conferences than her previous 15 years of scientific scholarship and publication combined.

Women in Medicine - Gail TomlinsonJonathan Epstein next spoke of the promise of cardiac regeneration, including many of the therapies no in trials to treat the damaged heart with stem cells. The heart, once thought to be a static organ after maturation with no capacity for self renewal, is increasingly recognized to have some potential to heal. Whether that potential can be invoked from within or whether external application of effort, such as injected stem cells, is required remains unknown. He mentioned the tug of war between knowledge of what is clinically-practical and what patients sometimes demand. As he puts it, the injection of stem cells to improve heart function has yet to produce results. However, patients find out about such treatments and may hear the incredible stories of someone who got the treatment and fully recovered, leading them to demand that treatment. The physician may believe it is a useless effort but may be inclined to treat anyway since the patient is asking.

The Women in Medicine Panel, moderated by Jill Baren, MD, and featuring Gail Tomlinson, MD, PhD; Juliane Wardenburg, MD, PhD, and Dianna Milewicz, MD, PhD, contained excellent advice for all trainees, men and women alike. Dr. Tomlinson (above left) spoke of three key elements to success in research: have a stable base, collaborate, and be creative, and balancing these is key for any physician-scientist. Dr. Milewicz spoke of the choices necessary as one navigates the career sea. You can be anything you want, but you have to be prepared to sacrifice something else so you can get what you really want. She emphasized prioritizing the things that are personally and professionally important to you when you make your career decisions. Dr. Wardenburg made the key point that you need to segregate your time, not taking work home to family and vice versa. All three had the same key message: you can do it, and you can succeed, but it will take a lot of work, dedication, and planning.

APSA's plenary session ended with a wild ride through the thicket of cancer genetics and genomics, driven by Levi Garraway, MD, PhD. The field is far more complex than simple single-gene mutations; epigenetics and chromosomal modifications abound. He spoke of his work on the complex process whereby many mutations and chromosomal alterations happen rapidly, much like evolutionary bursts, that he and others dubbed "chromoplexy." As it turns out, Dr. Garraway is a Tolkein fan, naming a complex process of unwravelling the many mutations and changes in a cancer Precision Heuristics for Interpreting the Alteration Landscape, or PHIAL. Lord of the Rings fans may remember Galadriel giving Frodo a phial containing the light of a silmaril. It was to "be a light for [him] in dark places, when all other lights go out." Dr. Garraway's PHIAL is also a light, giving patients with complex cancers hope that the mystery of their disease can be peeled back enough to effect care.


Business Meeting Highlights - Morning

Barry Coller, MDDania Daye, APSA's President, welcomed everyone to the business meeting and gave us a brief update on the state of APSA and what we have accomplished over the last year. APSA membership is strong and we are focussing on opportunities to continue to grow moving forward. Jennifer Kwan, VP for External Affairs and Policy Committee Chair, told us about APSA's great policy efforts, including the Tomorrow's Physician Initiative and the effort by APSA to extend the USME Step 3 time limit for dual-degree students, particularly those studying the humanities and social sciences for their PhD. Michael Guo & Christopher Audu from the Finance committee spoke of the major effort this year to renew our NCI R13 grant and the success of APSA in recruiting new institutional members. Dylan updated us on APSA's many PR initiatives this year, particularly the new website launch and opportunities for local chapter grants (Apply today!). Taylor Heald-Sargent spoke of the major events planned, including this years regional meetings in the South (October 19th, UT Health Sciences Center, San Antonio), Southeast (October 26-27th, UAB School of Medicine), Midwest (November 9th, The Ohio State University), and Northeast (November 2nd, Temple University). Mark your calendars!

Following speeches by candidates for Executive Council positions, we heard from several of APSA's external collaborators. First, Barry Coller, MD (above left) spoke of research in medicine and importance as more than a leg of a three-legged stool but rather as the "fusion" of a many-legged stool including patient care, public health, and community. He described modern medical research as more than a ladder one slowly ascends over a career and more of a lattice, with innumerable pathways and opportunities to travel for physician-scientists. He also noted dual and dueling nature of the physician-scientist, straddling the worlds of clinical medicine and medical research, and the important challenges but equally important benefits.

Neelum Aggarwal, MDAmy Kaji, MD, PhD of the ACEP revealed the many exciting paths for a physician-scientist in emergency medicine. She described the field as optimal for interdisciplinary research and health services research and reminded us the the key, named role for emergency care research in the Affordable Care Act. Neelum Aggarwal, MD (right) of the AMA Women Physician's Congress spoke of the challenges facing women physician-scientists and her organization's role in assisting them, particularly a series of mentoring programs targeting medical students and practicing physicians. Jackie Wong, President-Elect of the American Medical Women's Association, followed with the many networking, grant, and support resources her organization offers to women physician and physician-scientist trainees at all levels. She spoke highly of the APSA partnership and our existing collaborative efforts, including the Tomorrow's Physician survey and presentation of the results of that survey by APSA at the AMWA annual meeting. She encouraged APSA members to contact her with any questions or ideas for future collaborations: want@amwa-student.org. Finally, Dane Chetkovich, MD, of the American Neurological Association spoke of the support of his organization for any physician-scientist trainees considering neurology, including an E-advising program and mentorship opportunities for trainees.

Evan Noch, PhD, President-Elect of APSA, gave the closing remarks and outlined his vision for the next year for APSA. He set a goal of 200 attendees at each regional meeting and will work to standardize out partnership process to encourage and facilitate more partnerships like those with the external collaborators noted above. He will work with Ivayla Geneva to strengthen APSA's financial position for the long term, launching an investment strategy and building on APSA's success this year with increasing institutional memberships. Following his speech, members broke off into small groups by training phase to discuss how APSA can best help trainees at their level.

Congratulations to the recipients of AAP, ASCI, and APSA travel awards for 2013!

ASCI/AAP Travel Award Recipients

  • Feras Akbik, Yale University
  • Joseph L. Alge, Medical University of South Carolina
  • Neal Amin, Salk Institute
  • Vafa Bayat, Baylor College of Medicine
  • Lauren K. Brady, University of Pennsylvania
  • Ryan A. Denu, University of Wisconsin-Madison
  • Matthew L. Hedberg, University of Pittsburgh
  • Annie L. Hsieh, Johns Hopkins University
  • Tiffany Y. Hsu, Baylor College of Medicine
  • Rajan Jain, University of Pennsylvania
  • Jiyeon S. Kim, University of Pennsylvania
  • Leo Y. Luo, Broad Institute of Harvard and MIT
  • Nicholas O. Markham, Vanderbilt University
  • Kyle W. McCracken, University of Cincinnati/Children's Hospital
  • Brian D. Muegge, Washington University School of Medicine
  • Pankaj Pal, Washington University in St. Louis
  • Warren W. Pan, University of Michigan
  • Tyler P. Rasmussen, University of Iowa
  • Cecinio C. Ronquillo, John A. Moran Eye Center, University of Utah
  • Marc S. Sherman, Washington University in St. Louis
  • Jane W. Symington, Washington University in St. Louis
  • Maria C. Trissal, Washington University in St. Louis
  • Christine L. Tung, University of California San Diego
  • Samuel E. Vaughn, Cincinnati Children's Hospital and Medical Center
  • Yanjia J. Zhang, Harvard School of Public Health

APSA Travel Award Recipients

  • Christopher O. Audu, Dartmouth
  • Kristen A. Batich, Duke University
  • Douglas M. Bennion, University of Florida
  • Sonali J. Bracken, University of Connecticut Health Center
  • Andres Chang, University of Kentucky
  • Irene Chernova, University of Pennsylvania
  • Stephen M. Chrzanowski, University of Florida
  • Dania Daye, Perelman School of Medicine at the University of Pennsylvania
  • Adam C. Diehl, Johns Hopkins University
  • Sarah E. Greene, Washington University in St. Louis
  • Brittany L. Gregory, University of Pennsylvania
  • Emily N. Guhl, University of Chicago
  • Bianca N. Islam, Georgia Health Sciences University
  • Stephanie R. Jackson, Saint Louis University School of Medicine
  • InYoung Kim, University of Chicago
  • Katherine L. Knorr, Mayo Clinic
  • Samuel D. Quaynor, Georgia Health Sciences University
  • Amy J. Reid, University of Texas Medical School at Houston
  • Michael J. Ripple, Louisiana State University Health Sciences Center
  • Casey S. Seldon, Georgia State University
  • Lulu Sun, Washington University in St. Louis
  • Josephine W. Thinwa, University of Texas Health Science Center San Antonio
  • Ting-Lin Yang, University of Pennsylvania
  • Wan R. Yang, Johns Hopkins School of Medicine
  • Tresa E. Zacharias, University of Texas Southwestern Medical Center